Route 249 is a 6.16-mile-long (9.91 km) freeway in the southwestern part of the U.S. state of Missouri.

Route 249 begins at an interchange with I-44, I-49, and US 71 east of Joplin in Jasper County, where the road continues south as I-49/US 71.

[1] After an agreement between EPA and the state of Missouri, the Missouri Highway and Transportation Department built the Route 249 highway bypass through four miles (6.4 km) of contaminated land on the site in 2001.

The project adaptively reused mine wastes as fill material.

Cleanup of the Superfund site began in 2007, and the Route 249 bypass opened to the public in 2008.