Route 571 begins at a fork from the right-of-way of I-49 and US 71 (Trooper Charles P. Corbin Memorial Highway) southbound.

After turning back to the north, the designation changes once more to South Garrison Avenue.

The two highways create a commercial strip down West Central, crossing under the railroad near North Parsons Street.

The highway was moved its current route along Central Avenue to take traffic off of the two bridges near Kendricktown.

The section between Central Avenue and Kendricktown is no longer part of the state highway system.