In 1964, residents of Jasper County, Missouri approved a $2.5 million bond issue to begin construction on a new campus, where the university is currently located.

The Taylor Performing Arts center was completed in 1973 and the Richard M. Webster Communications and Social Science Building opened in August 1992.

The building, which had its groundbreaking on May 19, 2008, was built with money secured by MOHELA and distributed to MSSU by the state of Missouri.

Billingsly Student Center was the headquarters for volunteer efforts run by Americorps St. Louis and was the coordination area for identifying victims and survivors.

On May 29, 2011, Barack Obama, who was inspecting the damage, spoke at the Taylor Performing Arts Center.

Spiva Library (opened in 1967) was the first building built on the current campus following the properties purchase for use by what was then Missouri Southern College.

The library is named after prominent Joplin businessman George A. Spiva (1904–1967),[8] who was a major donor and supporter of the school.

Prior to 1987, the social sciences department utilized some areas of the building for classrooms and offices.

[10] This building houses the biology and environmental health, chemical and physical sciences, and mathematics departments.

Jay Nixon announced that he would request more than $5.2 million in funding from the state legislature for renovations to the building.

It is also home of the Spiva Gallery and is connected to both the Taylor Performing Arts Center and the Bud Walton Black Box Theatre.

Billingsly served in that capacity from 1964 until his death and supervised the construction of the original buildings on the campus.

When Stephens learned of the search for a new campus for the college, he worked with George A. Spiva and Morgan Hillhouse so the land could instead be used for that purpose.

The center now houses some of the programs falling under the biology and environmental health department in the School of Arts and Sciences, including the cadaver lab.

The 2,000-seat performing arts center was built on a $1 million bond and is home to the theatre department.

[15] Formerly known as Matthews Hall and named after Norval M. Matthews (1895–1977), an original member of the school's board of regents from 1965 until his death, the building and the school of business, which has resided in it since its construction, were renamed after Plaster in 2006 when he made the largest donation in the college's history.

Prior to this building's construction, the school of business had been located in the former Mission Hills mansion, today the Ralph L. Gray Alumni Center, from 1969 to 1980.

The building cost $7.5 million at the time of its construction and is home to the social sciences, communications, foreign languages, and international studies departments.

The building, also known as the Mission Hills mansion, is the oldest structure on campus, built in 1926 as the private home of Lucius Buchanan.

When the property was purchased for use as the university's campus in 1964, the mansion was originally used by then President Leon Billingsly for his office space.

It was located in a formerly private residence that was near Joplin Junior College's first home at the corner of 4th Street and Byers Avenue.

The nearly 100-year-old structure still stands and now serves as the Joplin public school district's Memorial Education Center.

It remained popular and in use even after the construction of the much larger and modern Thomas E. Taylor Center for Performing Arts in 1973.

The original space had been expanded and at previous times housed the school of business and the department of social sciences.

The building served various other purposes as office space and eventually storage for the university before being razed in 2005.

The Quads, opened fall of 2015, is a three-story complex that features 51 student apartments the vast majority of which will be four bedrooms.

SS strives to find solutions to campus issues by making policy recommendations to the administration.

SS is a forum for problems, concerns, questions, suggestions, and ideas as they relate to student life on campus.

CAB is a student-run programming board dedicated to enhancing the college experience at Missouri Southern.

The Lions play in NCAA Division II as a member of the Mid-America Intercollegiate Athletics Association.