They participate in the NCAA's Division II and in the Mid-America Intercollegiate Athletics Association (MIAA).

The current head football coach is Matt Williamson, who has held the position since 2017.

Partridge became Missouri Western's all-time wins leader on September 30, 2006 as the Griffons defeated Truman State University.

His current total of 149 career victories ranks third on the MIAA all-time list.

[3] The school has been the summer training camp for the Kansas City Chiefs since 2010.