The members of this five-piece band adopted pseudonyms as stage-names including: Drunken and Misery on guitars, Dirty Von Arse on bass, Dave Cunt on vocals and Migg on drums.
In 2001, Mistress released two demos, entitled Fuck Off and Lord Worm, which got them signed to the underground Rage of Achilles extreme music label.
The band's ability to create filthy sonic rage ensured that they were soon picked up by the much larger Nottingham-based Earache Records, who issued Mistress' third full-length album In Disgust We Trust in June 2005.
On 23 April 2007, they released their fourth studio album through FETO Records, entitled The Glory Bitches of Doghead, which has dropped the sludge sound in favour of enhancing the grind elements.
The album also has an ambient track running throughout (consisting of various noises, including what seems to be rain) created by Misery, which can be heard distinctly between songs, adding depth to the vicious music being played.