The youngest of six siblings, Talbot graduated from Canyon View High School in Cedar City, Utah and was a member of the Salt Lake Tribune's All-State second team during his senior season.

On July 12, 2006, during the All-Star break, Talbot, along with shortstop Ben Zobrist were traded to the Tampa Bay Devil Rays for outfielder Aubrey Huff.

Talbot earned the Devil Rays Minor League pitcher of August after he went 2-1 with a 1.96 ERA and led all of Double-A baseball with 47 strikeouts.

He was a member of the Montgomery Biscuits during their 2006 league championship season and was named minorleaguebasell.com's best Double-A playoff performer.

Talbot made his Major League debut on September 15, in relief of Scott Kazmir, and pitched 3 innings, giving up 4 earned runs and striking out two batters while walking three against the Boston Red Sox.

Talbot made his first Major League start against the Baltimore Orioles on September 23, 2008, during the second game of a double header and did not figure in the decision.

[6] On August 20, 2013, Talbot signed a minor league contract with the New York Mets organization and was assigned to the Triple-A Las Vegas 51s.

On June 30, 2014, Talbot signed with the Long Island Ducks of the Atlantic League of Professional Baseball.

On May 20, 2017, Talbot signed with the Sugar Land Skeeters of the Atlantic League of Professional Baseball In 2017 he appeared in 21 games (19 starts) across 110 innings he went 9-3 with a 3.03 ERA and 108 strikeouts.

[15] On March 6, 2019, Talbot signed with the Sugar Land Skeeters of the Atlantic League of Professional Baseball.