Weiss' career has included editorial photography for The Boston Globe,[1] portraiture for national advertising campaigns[citation needed] and art installations for corporate functions.

[5] That same year, Weiss guest lectured at the Boston Center for Adult Education[6] and Open Show: New York.

[7] Weiss was a semifinalist for Hasselblad's 2012 Masters series that celebrates the best in both established and rising photographic talent.

[8] In November 2013, Humble Hues published a book titled Dogs in Thought, which features Mitch Weiss' photographs; benefits went to the MSPCA-Angell and the Animal Rescue League of Boston.

[9] In late 2011, Weiss submitted a 2008 portrait he had taken of Lady Gaga, for auction by ARTcetera on behalf of Boston's AIDS Action Committee.