A one-shot by Kishimoto reveals that Mitsuki is an experiment created by the Legendary Sannin and former enemy of Naruto, Orochimaru, who allowed him to take his own path in life.

He originally had a shoulder length bob, but the author decided to change his hair to make him look more appealing, giving him a short white hairstyle instead.

"[3] Once the Boruto: Naruto Next Generations anime started, the director said that, while in the beginning Mitsuki and Sarada Uchiha were only classmates, the two would have "a more developed relationship from now on".

[11][12] He later accepts a mission to help Boruto, Kawaki, Sarada, Shikadi, Inojin, and ChoCho keep an eye on Eida and Daemon.

[22] Critical reception to Mitsuki's character has been mixed based on his limited appearances in the film's story as well as his role in the printed and animated series.

Thais Valdivia of Hobby Consolas stated that while Mitsuki's characterization was not properly executed in the film due to his limited appearances, his post-credit scenes would surprise the audience because of the revelation behind his heritage.

[23] The Fandom Post writer Chris Homer expressed a similar belief regarding the limited exploration of Mitsuki's character until the film's ending.

[25] Similarly, Amy McNulty of Anime News Network praised Daymond's performance, saying that while being "calm, collected, and oftentimes emotionless, the voice helps lend the character much of his mystery".

[28] Similarly, Melina Dargis, another The Fandom Post writer, considered Mitsuki's chapter the best in the first volume of the Boruto manga due to his connections with Orochimaru, and she felt it could have been used in the film.

[29] Nik Freeman of Anime News Network found Mitsuki's backstory one of the best in the franchise's history because it was not a rehash of prior story arcs.

Rebecca Silverman of the same site wondered how Mitsuki's origins might clash with Boruto's as the series' main theme due to the issues they both face: the relationship between children and their parents.

[30] After Mitsuki had debuted in the Boruto anime television series, McNulty wrote that while his introduction was overshadowed by the episode's focus on his ninja academy teacher Shino Aburame, his role fitted into the story and she still found him mysterious.

[31] Sam Stewart of IGN had similar thoughts, saying that, like Sarada, Mitsuki was not properly introduced in his debut because the plot focused on Shino.