Combat functions similarly to the previous Jump fighting game, such as J-Stars Victory VS, Dragon Ball Xenoverse sub-series, Naruto: Ultimate Ninja Storm sub-series and One Piece: Burning Blood, with players moving around a 3D space and utilizing various combos and special moves to attack their opponents.

When the real world collides with many of the Shōnen Jump universes, humanity is invaded by the "Venoms", an army of mind-controlled villains led by Kane and Galena.

In order to fight back, many heroes are recruited to join the "Jump Force" under the leadership of Director Glover and his AI partner Navigator.

After an amnesiac girl named Angela is rescued, several members of the Jump Force suddenly become possessed by evil auras during missions, leading them to suspect a traitor is among them.

She steals the collected umbras cubes and gives them to her master Kane, a man seeking to wipe out humanity in revenge for the deaths of his family.

Having outlived his usefulness, Galena seemingly kills Kane and proceeds to stall the heroes to allow Prometheus to continue his plans.

The villains form a temporary truce with the heroes, while a still-alive Kane uses the last of his strength to give his cube to the player and Goku empowers them further with the energy from all of the Jump Force, allowing them to destroy Prometheus.

Meanwhile, Light finds an umbras cube left behind by Prometheus, planning to use its dark energy to re-power his Death Note.

In addition, players are allowed to create their own unique playable character, customizing them with abilities, outfits and accessories earned through gameplay.

The Switch version, titled Jump Force Deluxe Edition, includes the downloadable content from the first Character Pass and was released worldwide on August 28, 2020.

It was delisted from digital stores along with its downloadable content on February 8, 2022, and the shutdown of its online server ranked matches happened 6 months later on August 24, 2022.