[9] The teams, which were made up of both male and female wrestlers from both the Raw and SmackDown brands, were picked by their respective general managers, Kurt Angle and Daniel Bryan.

During the second episode, Angle and Bryan announced that the first week of Mixed Match Challenge received 35 million total engagements.

[12] The Miz and Asuka won the inaugural Mixed Match Challenge tournament, earning the $100,000 for the Rescue Dogs Rock charity.

In the second season, teams competed in a round robin-style tournament throughout the fourteen 30-minute, two match episodes, in order to qualify for the playoffs.

[42][43] It was announced that Strowman was unable to compete in the Mixed Match Challenge playoffs after an elbow injury and was replaced by Curt Hawkins.

[44] On December 10, 2018, it was announced that Bálor was unable to compete in the Mixed Match Challenge semi-finals, being substituted by Apollo Crews.

R-Truth however did not participate in the Men's Royal Rumble match, as he was attacked by Nia Jax (who took the #30 spot) during his entrance.