Mizoguchi Shigemoto (溝口重元, November 14, 1680 – January 11, 1719) was the 5th daimyō of Shibata Domain in Echigo Province, Japan (modern-day Niigata Prefecture).

He was received in a formal audience by Shōgun Tokugawa Tsunayoshi in 1694 and became daimyō in 1706 on the retirement of his father.

He encouraged the development of scholarship and martial arts in the domain, and invited disciples of the noted Confucian philosopher and educator Itō Jinsai to the domain in 1715.

His grave is at the temple of Kisshō-ji in Tokyo.

Shigemoto was married to a daughter of Maida Toshiaki of Daishōji Domain, and after her death remarried Masa, the daughter of the kuge Nakanoin Michiomi.