Mizonokuchi Station (溝の口駅, Mizonokuchi-eki) is a junction passenger railway station located in Takatsu-ku, Kawasaki, Kanagawa Prefecture, Japan, operated by the private railway operator Tokyu Corporation.

It is 11.4 kilometers from the starting point of the Tōkyū Den-en-toshi Line at Shibuya Station,[1] and is the starting point of Tōkyū Ōimachi Line services, which branch off at Futako-tamagawa Station.

Musashi-Mizonokuchi Station on the JR East Nambu Line is located adjacent to it.

Mizonokuchi Station has two opposed elevated island platforms serving four tracks.

Mizonokuchi Station opened on July 15, 1927, with the name in Japanese originally written as (溝ノ口駅).