Mizuno Tadashige (水野 忠重, 1541 – 17 August 1600) was a retainer of the Tokugawa clan following the later years of the Azuchi-Momoyama period of the 16th century.

He participated in the Battle of Mikatagahara in 1573 against Takeda Shingen.

[1] In 1576, his brother, Nobumoto, was killed after betraying Tokugawa Ieyasu and later, he was given Kariya Castle.

In 1584, he participated in the Battle of Komaki and Nagakute against Toyotomi Hideyoshi.

In 1600, he was killed by Kaganoi Shigemochi on August 27 at Chiryu, Mikawa Province, a few days before the Battle of Sekigahara.