The game reserve is situated in lowveld wilderness in the southeast of Eswatini and is made up of acacia-dominated thornveld in the south and broadleaf sandveld in the north.

The reserve has many dry riverbeds, is dotted with waterholes and has a network of game-viewing roads.

[2] Mkhaya is staffed and patrolled entirely by local Swazi people.

[3] The game reserve was established in 1979 to save Nguni cattle, which were close to extinction, and has gone on to include other endangered species such as the black and white rhinos, hippopotamus pods, roan antelope, sable antelope, tsessebe, elephant and Cape buffalo herds.

[4][5] Birds of note include Narina trogon, purple-crested turaco, grey-headed bush-shrike, gorgeous bushshrike and pygmy kingfisher.