Mlilwane Wildlife Sanctuary is Eswatini's oldest protected area, owned and managed by a non-profit trust.

[1] The sanctuary serves as a headquarters for the Big Game Parks including Mlilwane's sister reserves Hlane Royal National Park and Mkhaya Game Reserve.

The southern section is predominately open grassland plains with middleveld vegetation, stretching up onto Nyonyane Mountain.

Tourist activities are concentrated in the southern section which can be explored by foot, horseback, mountain bikes or vehicle.

The northern section includes one of the highest points in the area at Luphohlo.