In 1528, Pánfilo de Narváez travelled through what was likely the Mobile Bay area, encountering Native Americans who fled and burned their towns at the approach of the expedition.
The next large expedition was that of Tristán de Luna y Arellano, in his unsuccessful attempt to establish a permanent colony for Spain nearby at Pensacola in 1559.
[4] During the American Civil War Mobile Bay was used as a major port for blockade runners bringing in badly needed supplies for the Confederacy.
During the Second World War, Mobile's shipbuilding industry expanded, and the city's population surged as both black and white migrants moved there for work.
On September 13, 1979, Hurricane Frederic entered the bay with winds reaching 145 miles per hour (233 km/h), destroying the bridge to Dauphin Island.
Thousands of boats, piers, and beach houses were damaged by waves exceeding 22 feet (6.7 m) high, and the battleship USS Alabama was pushed off her moorings, leaving her listing to port (tilted to the left).
On the Eastern Shore of the bay are found several small communities, including Spanish Fort, Daphne, Fairhope, Point Clear, and Bon Secour.
[7] On warm summer nights, the residents living around Mobile Bay sometimes enjoy the fruits of a mysterious natural phenomenon called a Jubilee, when fish and crabs swarm toward shore and can be easily harvested by people wading in the shallows.