[3] Federal Aviation Administration records show the airport had 286,956 passenger boardings (enplanements) in calendar year 2008,[4] 280,491 in 2009 and 277,232 in 2010.

[5] The airport is home to U.S. Coast Guard Aviation Training Center, Mobile, providing advanced training to U.S. Coast Guard pilots and aircrew in MH-65D Dolphin and MH-60T Jayhawk helicopters, as well as the HC-144A/B Ocean Sentry turboprop aircraft.

The Alabama Army National Guard's 1st Battalion, 131st Aviation Regiment's "B" Company is also located at the airport.

During World War II, the United States Army Air Forces used Mobile Regional Airport.

The Army used this airport as a basic (level 1) pilot training airfield, under contract to Waterman Airlines.

National Airlines Jacksonville-New Orleans flights stopped at the airport south of Mobile starting about 1939.

National Lockheed L-188 Electras appeared in 1962–63; later their Boeing 727-200s flew nonstop to New Orleans and Houston.

Starting in 1981 American Airlines Boeing 727-200s flew to Dallas/Fort Worth Airport via Jackson, MS or New Orleans, LA.

USAir (later US Airways and now merged into American Airlines) flew nonstop to Charlotte, NC in the mid 1990s with McDonnell Douglas DC-9-30s and Fokker 100s.

[9] Texas International arrived in 1979; successor Continental Airlines flew Boeing 737-200s and McDonnell Douglas DC-9-30s nonstop to Houston Intercontinental Airport in the late 1990s.

The terminal at Mobile Regional Airport has renovated shops and restaurants, such as local favorite Carpe Diem Coffee and Tea, car rental agencies, and handicap accessible elevators.

In the year ending October 30, 2021 the airport had 75,034 aircraft operations, average 205 per day: 72% military, 14% general aviation, 8% air taxi, and 5% airline.

[2] The major carriers out of Mobile are United Airlines and Delta Air Lines, based on the number of flights.

Delta Air Lines alone operates mainline passenger service from the airport and uses such jet types as the Boeing 717 and the Airbus A319.

Delta also operated the McDonnell Douglas DC-9-50 into Mobile prior to the retirement of this aircraft type from their fleet.

[citation needed] Low-cost carrier AirTran Airways served the airport for a time, but Delta Air Lines and other airlines matched fares on the routes that AirTran served, and passengers continued to fly the traditional network carriers.

The Mobile Airport Authority encourages passengers to use multiple airlines to stimulate more competition and lower fares, and it continues to work to attract a low-cost carrier.