The orchestra has performed repertoire from all musical styles and periods, and has hosted many artists, including Yo-Yo Ma and Renee Fleming.
In 1996, the organization's board began planning the development of a full-time professional orchestra to permanently reside in Mobile.
In 1997, the name of the company was changed to "Mobile Symphony, Inc," and in 1998 the orchestra held its first concert season.
In 2002, under the leadership of mayor Michael Dow, the company acquired a building at 257 Dauphin Street in downtown Mobile, which became the Larkins Music Center.
The building includes office space, a large recital hall, practice rooms, meeting facilities, and a landscaped courtyard.