He and Gus Greenbaum made the Flamingo Hotel & Casino in Las Vegas very successful after Siegel's murder.

Later in his criminal career, he began making trips to Las Vegas on Meyer Lansky's behalf in the early 1930s to franchise the syndicate's Trans-America race wire service.

Sedway was also instrumental in the financing and construction of the Flamingo Hotel when William R. Wilkerson ran into financial difficulties.

[3] Sedway served as a Clark County alderman, and was head of the United Jewish Appeal in Las Vegas.

[4] His name was merged with Gus Greenbaum's to inspire the name for the character "Moe Greene" in the American crime drama film The Godfather.