The river originates in the lower foothills of the Western Ghats at the Karadka Reserve Forest in the Kasaragod district.
Initially it flows through several hilly towns in the eastern region of Kasargod, namely, Badiyadka, Karadka, Mulleriya, Paika, Edneer and Nekraje.
From Nekraje, the river takes a meandering course enters the Malabar plains where passes the towns of Pady, Cherkala, Muttathody, Chettumkuzhy, Shiribagilu, Madhur, Patla, Kannathur, Peral, Mogral and Puthur.
[1] There is a significant patch of mangroves in the three-kilometer stretch of estuary where Mogral River merges with the Arabian Sea.
Two researchers reported sighting six individual Bar-Headed Geese (Anser indicus) on fresh water near the mangroves on 26 January 2009.