Today, Moguer and nearby Palos de la Frontera are home to the lugares colombinos, a tourist route of places associated with undertaking that voyage.

Moguer's river port continued to be an important site for seafaring and trade, exporting the local wines and other merchandise to the Americas, Russia and other European countries.

Besides being one of the lugares colombinos, Moguer is also known as the birthplace of poet Juan Ramón Jiménez, winner of the Nobel Prize for Literature and author of Platero y yo.

On the north it is bounded by the Río Tinto, the municipalities of Huelva, Niebla and San Juan del Puerto; on the south by the Atlantic Ocean and Palos de la Frontera; on the west by the Río Tinto and Palos de la Frontera; and on the east by Almonte and Lucena del Puerto.

Being located near the coast of the province of Huelva, Moguer has a Mediterranean climate (transitional between subtropical and temperate) with an Atlantic influence.

[9] The origin of human settlement in Moguer is lost in the remoteness of history and is surrounded by legend, as is the case for all the lands near the mouth of the Río Tinto.

The current municipality of Moguer was a focus of attraction for the people of the Iberian interior and of the eastern Mediterranean since ancient times, as evidenced by Neolithic, Phoenician and Roman archaeological remains.

Remains of amphorae, coins, bricks, tegulae with potter's marks and a fragment of 2nd-century CE Terra sigillata (a type of decorated pottery) confirm the existence of several Roman settlements with the limits of the present-day municipality of Moguer.

)[12] to ships arriving at the river port of Moguer from the Canary Islands, North Africa and Atlantic European countries.

Toward the end of the 15th century, the town had a population of about 5,000, and a city centre with several arterial roads, dominated by the Paris Church of Our Lady of Granada, the castle, the San Francisco convent and the Santa Clara monastery.

Later, upon his arrival from America, Columbus came promptly to the church of the Monastery of Santa Clara to fulfill a vow made when the Niña encountered a severe storm on the return voyage.

Many moguereños participated in the discovery and evangelization of the new lands,[16] among them Pedro Alonso Niño, discoverer of the coasts of Paria (Venezuela); Bartolome Ruiz, navigator, pilot on the "Famous Thirteen" expedition Francisco Pizarro and hence co-discoverer and of the Pacific; fray Antonio de Olivares, founder of the city of San Antonio, Texas; Alonso Vélez de Mendoza, leader of the group who repopulated the island of Santo Domingo (Hispaniola); the Franciscan Quintero, who accompanied the expedition of Hernán Cortés to Mexico; fray Andrés de Moguer, the first chronicler of Mexico; Diego García de Moguer, who took part with Ferdinand Magellan on the first trip around the world; and Juan Ladrillero, considered an independent discoverer of the Straits of Magellan.

The 1755 Lisbon earthquake caused extensive damage in the city,[12] leaving only the strongest buildings standing: part of the castle, the Santa Clara Monastery and the Chapel of the Hospital.

Ecclesiastically, Moguer had been the seat of the vicarage of the same name since the mid-15th century and also core of a deanery (arciprestazgo) whose area was broader than the old parish, which only extended as far as Palos de la Frontera.

The First Spanish Republic (1873–1874) also left its mark with the construction of road and bridge over the Río Tinto, basic infrastructures for the development of the municipality.

On 23 December 1881, poet Juan Ramón Jiménez—author of Platero y yo and winner of the 1956 Nobel Prize for Literature—was born in the house at number 1, Calle de la Ribera.

[17] The centuries-old strategy of economic prosperity based on the wine industry was frustrated in the early 20th century by the infestation of phylloxera.

Now, in the early 21st century, the economy of Moguer is largely driven by the growth of strawberries and raspberries; the construction industry and service sectors are also strong.

Moguer thrived thanks to the cultivation of wheat, wine grapes, esparto, hemp, and other crops, as well as continued prosperity in fishing.

The arrival in the early 20th century of phylloxera, a disease affecting vinifera grapes, was very harmful to Moguer's vineyards, but the industry has since recovered to a significant degree through the use of resistant rootstock.

At the end of the 1970s the "Las Madres" estate of started growing Fragaria x ananassa—the garden strawberry—which spread rapidly through the municipality and the rest of the province.

[18] At the same time, recent development of the urban center of Mazagón for tourism has increased the number of hotels and other short-term accommodations to constitute 12 percent of the municipal economy.

The businessman Antonio Medina Lama began the first local experiments with growing strawberries on his "La Madre" farm in the late 1970s.

The municipal hall (Spanish: ayuntamiento), known as the Casa Consistorial, is located in the Plaza del Cabildo, in the historic center of Moguer.

In the municipal and regional elections of 2023 the Gustavo Cuellar Cruz of left-of-centre Spanish Socialist Workers' Party-Andalusia (Partido Socialista Obrero Español-Andalucía, PSOE-A), was reelected to the mayoralty, which he has held since 2011.

The informative committees "Urban and Internal Regime", "Social Welfare", and "Economy and Development" are held on the first, second and third Thursday, respectively.

At the end of August, a solemn novena begins in her honor in the Parish Church of Our Lady of Granada, to culminate with the Principal Function of the Institute and the procession of the Señora through the city's streets for the day of the Nativity of Mary, September 8.

At present there are eight filial brotherhoods (hermandades) spread over the provinces of Huelva, Seville and Madrid dedicated to the patron saint of Moguer, who also participate in this celebration.

reynos e Señorios (...) Sabedes que nos habemos mandado a Christobal Colon que con tres carabelas vaya a ciertas partes de la mar oceana como nro.

logares e jurisdicciones que cada quel dicho Christobal Colon hobiere menester....Platero – le dije – vamos a esperar las Carretas.