Mohamad Ezam first became known when he was involved in the Reformasi movement in 1998 and became the first Youth Leader of the National Justice Party (KeADILan) in 1999.

He continued his studies at International Islamic University Malaysia (UIAM) in 1987 and received his bachelor's degree in economics (BEc) in 1991.

Mohamad Ezam's political journey began in the late 1990s during the Reformasi movement, a series of mass protests and rallies triggered by the dismissal of Deputy Prime Minister Anwar Ibrahim in 1998.

Mohamad Ezam, then a student, became deeply involved in the movement, which aimed to reform the Malaysian political system, fight corruption, and restore justice.

He was detained for a total of 18 months, and his imprisonment marked a significant period of his life that solidified his commitment to fighting for democratic reforms in Malaysia.

In the case of Mohamad Ezam Mohd Noor v Inspector General of Police & Others [2002]4 CLJ 309, the Federal Court ruled that the position of Article 5(3) of the Federal Constitution is unchanged based on Section 4(4) of the Human Rights Commission Act (SUHAKAM Act) 1999, and there is no urgent need to apply international rules/laws.

Mohamad Ezam said he was appointed as a senator because of the role he played in the non-governmental organization, Gerakan Rakyat Anti Korupsi (GERAK), where he also served as its president since 2007.

[27] In addition, he was appointed as the vice head of UMNO of Kota Raja division after won without contest on 21 September 2013.

Mohamad Ezam joined the Malaysian United Indigenous Party (BERSATU) in October 2016, after leaving UMNO in the same month.

[38][39] This led to the previous president of NewGen, G. Kumar Aamaan, making a police report and a complaint to the Registry of Societies Malaysia (ROS) requesting further investigation because the action in question violated the party's constitution and the agency's laws.

[40] The PBR party won't last long since Mohamd Ezam decided not to wait for the ROS to approve his request after two months.

[41] In the 2018 general election, Mohamad Ezam was expected to run for the Pekan seat, He will face his former boss, Najib Razak, who is the sole BN candidate.

[59] Mohamad Ezam has been selected by PRM as a candidate to contest in the Petaling Jaya parliamentary seat in the general election in 2022.

[61][62] Mohamad Ezam funded the Gerakan Rakyat Anti Korupsi (GERAK) and served as its president from 2007 until 2008, before he was accepted back into his old political party, the United Malays National Organisation (UMNO) in May 2008.

Mohamad Ezam's voice is often compared to that of Anwar Ibrahim, both known for their clear, resonant tones and strong, authoritative presence when speaking.

Mohamad Ezam’s articulation, intonation and emphasis on key points often mirror Anwar’s style, which has been noted by both supporters and critics.

On 27 May 2009, in the Hujah program on TV9, Mohamad Ezam denied that he had six boxes of corruption-related evidence when Anwar Ibrahim was imprisoned in the Sungai Buloh Prison.

Mohamad Ezam initially rose to prominence as a key figure in the Reformasi movement and was one of the founding members of the People's Justice Party (PKR), led by Anwar Ibrahim in 1999.

However, in 2008, Mohamad Ezam controversially rejoined United Malays National Organisation (UMNO), the ruling party he had previously criticized for corruption and undemocratic practices.

Mohamad Ezam's shift back to UMNO shocked many, especially his supporters within PKR, who saw it as a betrayal of the reformist ideals he had espoused.

His decision to leave UMNO again in 2016 to join the Malaysian United Indigenous Party (BERSATU), which was aligned with the opposition at the time, added to his controversial reputation.