Mohammad-Hossein Mirza (Persian: محمد حسین میرزا) was a Qajar prince, who governed Kermanshah twice, between 1821–1826 and 1829–1835.

In 1826, he was replaced by his brother Tahmasp Mirza due to his debauchery and lack of competence, although he later got back the position in 1829.

Additionally, he had long since lost the friendships of the tribes that his father had enjoyed exceptionally warm ties with.

Due to the remotness of Kermanshah, he was unable to assess the proportional forces of the three parties fighting for the throne.

[1] Together with other royal family members who were seen as possible challenges to the new government, he spent his final days imprisoned in the fortress of Ardabil.