Mohammad-Reza Lotfi (Persian: محمدرضا لطفی; 1 January 1947 – 2 May 2014) was an Iranian classical musician renowned for his mastery of the tar and setar.

[2] Encouraged by his older brother, he learned to play the tar and showed his talent by winning the first prize in Iran's Young Musicians Festival in 1964.

[3] The following year, he started his studies at the Persian National Music Conservatory in Tehran under Habibollah Salehi and Master Ali Akbar Shahnazi.

His other accomplishments were teaching at the Center for Intellectual Development of Children and Adolescents, researching folk music for National Radio and Television, and appearing at the Shiraz Arts Festival.

According to Hamid Dabashi, Lotfi's death marked "a crucial turning point in the history of classical Persian music and its spectacular rise and fall as a performing public art.