Mohammad Yunus Khalis (alternate spellings Yunis and Younas) (Pashto: محمد يونس خالص; c. 1919 – 19 July 2006) was a mujahideen commander in Afghanistan during the Soviet–Afghan War.

Unlike some other leaders of the Afghan mujahideen, Khalis depended more on his tribal support rather than religious to gather followers in his native Nangarhar province against the Democratic Republic.

Many prominent mujahideen commanders including Abdul Haq, Amin Wardak Faisal Babakarkhail and Jalaluddin Haqqani were affiliated with Hezb-e-Islami Khalis.

In 1987, Khalis met with President Ronald Reagan at the White House while in the United States following a U.N General Assembly Vote calling for the withdrawal of foreign troops from Afghanistan.

"[6] According to a statement from his son Anwar ul Haq Mujahid, leader of the insurgent group Tora Bora Military Front, Khalis died on 19 July 2006.