Mohammadzai (Pashto: محمدزی), also spelled Moḥammadzay (meaning "descendants of Mohammad"), is a Pashtun sub-tribe or clan of the Barakzai which is part of the Durrani confederacy of tribes.

[1][2] They are primarily centered on Kandahar, Kabul and Ghazni in Afghanistan as well as in the city of Charsadda in neighbouring Pakistan.

Their rule ended under Daoud Khan when the Communists took power via a Soviet-backed coup.

Mohammadzai are the most prominent and powerful branch of the Durrani confederacy, and are primarily centered on Kandahar.

Musahiban are the descendants of Sultan Mohammad Khan, also known as "Telai".