[29] He made his official Basel debut in a UEFA Champions League preliminary stage match against the Norwegian club Molde on 8 August, coming on as a substitute in the 74th minute.

[32] Salah scored his first UEFA Europa League goal in the quarter-finals on 11 April 2013, as Basel advanced to the semi-finals by beating Tottenham Hotspur 4–1 in a penalty shoot-out after a 4–4 aggregate draw.

[39] Salah was the subject of major controversy following the game, after he appeared to deliberately avoid shaking hands with the players of the Israeli club in both the home and away legs.

[52] Seven games later, on 22 March, Salah scored his first goal for Chelsea against Arsenal in the London derby, coming on as a substitute for Oscar, in a match which ended as a 6–0 home win.

[58] Although Salah only made three league appearances before his loan move to Fiorentina, Mourinho stated that he would receive a replica winner's medal from the club for his contributions that season.

[64] Twelve days later, Salah scored his first European goal for Fiorentina, as his side advanced to the round of sixteen of the Europa League, beating Tottenham 3–1 on aggregate.

[69][70] On 11 September, Fiorentina filed a complaint to FIFA, claiming that Chelsea had breached the agreed contract when they allowed Salah to join Roma on loan.

[105] He joined the club on 1 July upon the opening of the summer transfer window, becoming Liverpool's first Egyptian player,[106] and scored on his Premier League debut against Watford in a 3–3 away draw on 12 August.

On 26 November 2017, Salah scored the opener and refused to celebrate in a 1–1 home draw with his former team Chelsea out of respect for the club as well as victims of the Sinai mosque attack two days earlier.

In this game, he also broke a record of scoring 36 times in his debut season for Liverpool, and also became the leading goalscorer in Europe's top five leagues – overtaking Barcelona's Lionel Messi and Tottenham striker Harry Kane.

The Egyptian FA stated that this would have no effect on his availability for the 2018 FIFA World Cup in Russia, and that Salah would still be named in the team's final squad on 4 June.

In doing so, he became the joint-fourth fastest player to achieve the milestone, alongside Fernando Torres, and behind only Andy Cole, Alan Shearer and Ruud van Nistelrooy.

[149] On 5 April, he scored his 50th Premier League goal for Liverpool in a 3–1 win over Southampton and in the process broke Torres' record to become the fastest player to reach the milestone for the club, doing so in his 69th appearance.

[150] It also saw him become the third fastest player to reach the milestone for a single club in the Premier League era, behind Shearer for Blackburn Rovers, in 66 appearances, and Van Nistelrooy for Manchester United, in 68.

[159][160] In December, Salah ended fifth in the voting polls for the 2019 Ballon d'Or, and made his 100th Premier League appearance later in the month, marking the occasion with a goal and assist in Liverpool's 3–0 win over Bournemouth.

[213] On 21 February, Salah became Liverpool's top goalscorer in European competitions after scoring the second goal in the Champions League match against Real Madrid in the first leg of the round of sixteen.

[225] On 26 October, Salah scored the last goal in a 5–1 victory against Toulouse to become the highest-scoring Premier League player in European competitions, overtaking Thierry Henry.

[228] On 9 December, Salah scored his 200th goal for Liverpool in a 2–1 win away to Crystal Palace in the Premier League to become the fifth player at the club to reach the landmark, following Ian Rush, Roger Hunt, Gordon Hodgson and Billy Liddell.

[234] On 17 August 2024, Salah broke the record for the most goals scored on opening day in Premier League history after netting in a 2–0 win over newly promoted Ipswich Town.

[235] On 2 October, with a curled goal in a 2–0 victory over Bologna in the Champions League, he surpassed Didier Drogba as the all-time highest scoring African player in the competition.

[251][252][253] On 12 February, in the last Merseyside derby at Goodison Park, Salah became the fourth player to record 100 goal involvements in as many Premier League matches, after Alan Shearer, Thierry Henry and Robin van Persie.

[267] On 10 September, Salah scored his sixth tournament goal in a 4–2 win over Guinea, securing Egypt a 100% record to finish their qualifying group and becoming the joint-top scorer among all African teams in the qualification stages.

[269][270] On 19 November, Salah scored the opening goal in a 2–1 away defeat to Tunisia, as Egypt missed out on qualifying for the Africa Cup of Nations finals for a third consecutive time.

[284] On 16 June 2019, Salah provided two assists after coming on as a substitute in 3–1 win over Guinea in friendly warm-up game for the 2019 Africa Cup of Nations on home soil, wearing the captain's armband for the first time in his international career.

[316] His technical skills, pace, left foot, goalscoring, position and direct playing style led him to be nicknamed the "Egyptian Messi", in the Italian media.

[326] Salah has also revealed that his favourite food is kushari, an Egyptian working class dish in origin that is usually made from rice, pasta and lentils and topped with a variety of options including spiced tomatoes, chickpeas and onions.

[330] He appeared in an Adidas 2018 World Cup commercial along with other players who are also sponsored by them, including David Beckham, Lionel Messi, Paul Pogba and singer Pharrell Williams.

[333] Salah is active in regeneration projects in Nagrig, his hometown where most people live in poverty, donating money to help build a school and hospital.

[354] After Egypt's exit from the World Cup, Salah stayed in his home country for his pre-season holiday, and in late June, his address was accidentally leaked on Facebook.

[355] During Liverpool's 2018 pre-season tour in the U.S., American artist Brandan Odums created a mural in New York City's Times Square area displaying Salah in an Egypt kit, with the player later posting an image on social media posing next to it.