His films include Nandini Oppol (1994), Kaathil Oru Kinnaram (1996), Dravidan (1998), Kattathoru Penpoovu (1998), Saavithriyude Aranjaanam (2002), Payum Puli (2007), Evadaina Sare (Telugu language)[2] (2007), Grihanathan (2012) and Chandragiri (2018).

[3] Mohan Kupleri hails from Payyanur, Kannur District, in the state of Kerala.

He is married to Rajasree, and they have two children: Dr. Ambili Saikiran and Akhil Mohan.

He collaborated with Adoor Gopalakrishnan on several award-winning films, including Elippathayam, Mukhamukham, and Anantaram, which garnered numerous national and international accolades.

In addition to his work in cinema, Mohan Kupleri has scripted and directed television serials and commercial advertising films.