Moira station is the oldest building on the NI Railways network today having been opened on 18 November 1841.

[3] In March 2014, NIR started construction of a new footbridge at the Portadown end of the station.

During the construction of the station and the railway thousands of skeletons were unearthed, leading to a greater understanding of the Battle of Moira, the largest battle in the history of Ireland, which had occurred in 637 and the previous details of which were much less well known.

Later the Great Northern Railway of Ireland had a much more extensive system with trains to Omagh, Enniskillen, Bundoran, Strabane and Derry/Londonderry being linked, which in the 1950s and 1960s was closed west of Portadown.

The station is also passed through by the Enterprise intercity service from Belfast Grand Central to Dublin Connolly on the Belfast-Dublin railway line.