It borders the towns of Las Torres de Cotillas, Alguazas, Lorquí, Ulea, Archena, Abarán, Blanca, Murcia and Fortuna.

Molina de Segura is home to confectionery makers Vidal Golosinas, Jake S.A. and Sánchez Cano (also known as Fini).

There is evidence of human presence in the municipality from the Middle Paleolithic that consists in a site named Las Toscas-El Chorico.

The Visigothic king Theodemir and the governor of North Africa Abd al-Aziz ibn Musa signed the Treaty of Orihuela.

It established Muslim sovereignty in the southeast of Spain, that includes the current municipality Molina de Segura.

The nobleman Alonso Fajardo granted excellent condition to the people from Christian kingdoms who moved to Molina de Segura with a document named Carta Puebla in 1396.

When Henri III of Castile was the king, the adelantado (governor) Alfonso Yánez Fajardo was bestowed the territory.

[11] The social and administrative structures didn't vary considerably from the beginning of the Early Modern Period until the Spanish confiscation.

The apogee also affected the town and a specific phenomenon of that is the construction of Nuestra Señora de la Asunción Church in 1765.

[12] In the second half of the 19th century, tinning economic activities of the grown products started in Molina, but they were performed in a crafted way during the first decades.

[13] The town of Molina de Segura is located in Europe, in the east of the Iberian Peninsula, belonging to the kingdom of Spain, and part of the Region of Murcia.

Some landforms in the municipality are Sierra de la Espada (a mountain range)[14] and Rambla del Chorillo.

There is a long tradition of huerta, roughly translated kitchen gardens, in the region that are grouped into the inherited irrigation.

The smaller hamlets, Fenazar, Valientes (The brave), Campotéjar Alta, Campotéjar Baja, Comala, La Espada (The Sword), Rellano (Landing), Albarda, La hornera and Romeral are on dry land with little production of cereals, olives and sheep.

The airports of Alicante and San Javier and the seaport of Cartagena are located half an hour away by car.