It shares borders with Fortuna in the north, with Murcia in its west and south and with the province of Alicante in the east.

There is a remaining structure of the period of Muslim occupancy in the Iberian Peninsula and it consists in a watermill.

The first documentary reference in which the toponym Santomera appears dates back to the Reconquista era.

The king of The Taifa of Murcia signed a treaty with Castile in which the territory would become part of Castilian rule in 1243.

The independence from Murcia municipality ceased when the absolutist king Ferdinand VII reached the throne.

[6] In 1879, a flood occurred in the current municipality and it caused high damages to crop lands, herds, dwellings and even some people deceased.

[6] A development took place in Santomera in 1970 decade in its economic branches, agriculture, industry and trade.

A document was handed in to Murcia town council in 1971, but the issue began to be addressed a year later.

The organisation considered Murcia town council action as illegal and invalid.

The process for Santomera own town council started, it progressed slowly and would last some years.

The least populated place is a village named Orilla del Azarbe that is in the south of Santomera.

The town also hosts a centre of the national institution for language teaching named Escuela Oficial de Idiomas.