[2][3][4] In 2017, BBC named her one of the 100 most influential women, and the following year, Forbes featured her among its "30 Under 30" Asia list along with nine other Pakistani individuals.

"[7] Born in Quetta and raised in Islamabad, Mustehsan earned her degrees in Biomedical Engineering and Applied Mathematics after double majoring at Stony Brook University.

[8][9] Mustehsan rose to prominence as a co-singer and writer in Farhan Saeed's single "Pi Jaun", and later sang the acclaimed song "Awari" for the Indian thriller film Ek Villain (2014).

[3][13] Mustehsan's next three singles, "Aaya Na Tu" (2018), "Baari" (2019) and "Uchiyan Deewaran" (2020) peaked on YouTube within 24 hours upon their releases and all of them have since gained more than 200 million views collectively, and received critical compliment for her voice in the original soundtrack of the television series Alif (2019).

[16] Due to her father's profession as an army officer, the family was posted in a number of places in Pakistan and around the world, including Multan, New York, Paris and Kyiv, but was particularly raised in Islamabad, which she considers as her hometown.

[17] Mustehsan completed her A-Level from Lahore Grammar School and later moved to the United States for higher studies and graduated with degrees in Biomedical Engineering and Applied Mathematics from Stony Brook University in 2016.

[20] Mustehsan at first learnt to play violin and sang in public for the first time in a choir of her grade school, without any formal music training.

[2] Her first encounter with the music came in 2004, when she recorded her first cover of Irish singer Damien Rice's song "The Blower's Daughter".

[41][42] On 3 November, "Afreen Afreen" became the fastest Pakistani origin video to mark 100 million views on YouTube, and become the most viewed Pakistani origin YouTube video on 10 November, leaving behind Atif Aslam's rendition of "Tajdar-e-Haram" and Imran Khan's "Amplifier".

[43][44] That same year, she collaborated with the Coke Studio for a second time, and released three songs, one of which was the "Qaumi Taranah" (national anthem of Pakistan).

[50][51] Mustehsan began 2018 with the single "Aaya Na Tu", which she sang with the Indian singer Arjun Kanungo.

[52][53] Composed by Kanungo, and written by Kunaal Vermaa, the single was released under the label of Universal Music India.

[14] The single was shot in Bangkok, and Mustehsan said that the song addresses "rejection, pain and the burden of true love".

Upon release, the song raised nation-wide hue and cry since the classic was widely believed to be destroyed by both singers.

[59][60] Later that year, she collaborated with Sahir Ali Bagga for the second time for Jawani Phir Nahi Ani 2, where she performed the song "Ishq Hoa Jo Tari", which was filmed on Sara Loren and was a commercial success.

[66][67] In September 2016, Mustehsan confirmed and announced her engagement on Twitter to Ali Naqvi, a US based banker in California.

"[76] In an online interview, Mustehsan stated that she had donated all of her earnings of 2016 to make water-wells in the Thar desert of Sindh.

"[40][15] In 2017, Mustehsan was a part of the United Nations Women "Beat Me" campaign, that aimed to address the issue of domestic violence in the country.

[82][83] In addition to appearing, she also recited a part of the poem "Lab Pe Aati Hai Dua", in the Sindhi language for the advertisement.

[85][86] That same month, Mustehsan lend her support to the "Taleem Do" initiative, a non-profit right to education program, based in Tharparkar.

[15][16][11] Mustehsan often features among the nation's most beautiful people and the most popular singers list, and is among the most followed Pakistani celebrities on social media.

[95] In December 2016, Mustehsan became the goodwill ambassador of a cricket team, Islamabad United for the Pakistan Super League.