Monatepil is a calcium channel blocker and α1-adrenergic receptor antagonist used as an antihypertensive.

[1] The synthesis of monatepil was first disclosed in patents filed by Dainippon Pharmaceutical.

[2] The amino group of the dihydrodibenzothiepin (1) is first reacted with the acid chloride of 4-chlorobutyric acid, to give the amide (3).

This is then used to alkylate para-fluorophenylpiperazine (4) to yield monatepil.

This drug article relating to the cardiovascular system is a stub.