[1][2] She has previously played leading roles in the control of Ebola epidemics in Uganda, the Democratic Republic of the Congo and in the West African country of Sierra Leone.
At first She taught Veterinary Pharmacology, Physiology, Biochemistry, but later switched to Microbiology, immunology and Molecular Biology after completing her Postgraduate studies in USA.
In 2008, Musenero was employed by the African Field Epidemiology Network (AFENET), as a Consultant Epidemiologist and Senior Program Officer, based in Kampala, Uganda.
In 2011, she joined SDS (Strengthening Decentralization for Sustainability) Project as was Regional Director for Central Uganda, serving in that capacity until 2013.
She served briefly as the Assistant Commissioner, Epidemiology and Surveillance at the Ministry of Health in Uganda, in 2015, but was requested to return to Sierra Leone to continue supporting the Ebola response until 2017.