Mono Mills is a small village in the town of Caledon, within Peel Regional Municipality in Ontario, Canada.

Mono Mills emerged as a hamlet in the 1820s.

The Mono Mills name is derived from its location situated partly in Mono Township, combined with the fact that a grist mill once operated here.

Industry and businesses sprung up around the mill and the population grew enough that the Mono Mills post office opened in 1839.

By the 1870s the grist mill was flourishing and was supported by numerous businesses including a wagon works, blacksmith shop, harness shop, three general stores and four hotels as a lot of trade and commerce was conducted here.