Monocerin PKS produces an intermediate with initially a high degree of reductive modification but ends with a classical β-polyketide moiety.

Dihydroisocoumarin is the first PKS-free intermediate which would be formed from the reduced heptaketide whose assembly pathway is shown in figure 1.

[2] Ketosynthase, ketoreductase, dehydrates, enol reductases and cyclisases are shown as domains of the Monocerin PKS and methyl transferase is considered to be a tailoring enzyme.

[3] Monocerin produced by Exserohilum turcicum causes Northern Corn Leaf blight disease in maize.

The maize will develop brown lesions on its leaves and will have decreased viability in its root cap cells.