Mon Health Medical Center's roots can be traced back to the early 1900s with the establishment of the privately owned City Hospital at the corner of Wiley and Prospect streets in Morgantown, WV.
Dr. Heiskell added a Nursing School to supply Heiskell Memorial with well-trained nurses, and he operated the facilities until the early 1950s, when the Pallotine Order of the Roman Catholic Church purchased the hospital and renamed it "St. Vincent Pallotti Hospital.
The latter's son, C. Andrew Heiskell, M.D., also a surgeon, would join the staff of Monongalia General Hospital in 1973 and continues his practice there as of 2017.
In 1943 the county appointed an independent board of directors to govern the facility, making it the voluntary hospital it is today.
In July 2008, the hospital opened its new Hazel Ruby McQuain Tower, which features all private inpatient rooms, a Women's Imaging Center, a large Emergency Department, an expanded Imaging Department, and an Intensive Care Unit.