Its watershed includes parts of the Mount Airy and Germantown neighborhoods of Philadelphia.
The Monoshone lies completely within the City of Philadelphia and is part of a trout-stocked fishery.
During the eighteenth century, the stream was dammed at several points to power more mills.
In recent years, the creek has been polluted from an unknown source that may have to do with a sewer line routed next to the buried stream along Lincoln Drive.
A controversial wetlands restoration project in Saylor's Grove was built in 2006, in part an attempt to reduce the pollution of the stream by providing a natural buffer for some of the water flowing into it.