Produced by Whitewolf Entertainment, the program deals with the search for various monsters of interest to the cryptozoology subculture and paranormal entities reportedly witnessed around the world.

The purpose of the show is best described by the narrator, Stan Bernard, in the introduction: Witnesses ("People" for Season 4) around the world report seeing monsters.

Science searches for answers...on MonsterQuest.History channel revived the MonsterQuest series for special episodes beginning on August 28, 2020.

Media coverage of purported "cryptids" often fails to provide more likely explanations, further propagating claims made by cryptozoologists.

[4] In a statement made March 24, 2010 on the cryptozoological blog CryptoMundo, MonsterQuest producer Doug Hajicek announced that History Channel had canceled the series midway through 4th season.