[6][1][7] Based on the eponymous fashion doll franchise by Mattel and produced by its television division and Brightlight Pictures, the film stars Miia Harris, Ceci Balagot and Nayah Damasen as Clawdeen Wolf, Frankie Stein and Draculaura.

Respectively along with Case Walker, Steve Valentine, Jy Prishkulnik, Lina Lecompte, Justin Derickson, Marci T. House, Scotch Ellis Loring, Nasiv Sall and Lilah Fitzgerald and newcomers including Ana Ortiz, Bonale Fambrini, Kyra Leroux and Salena Qureshi.

On the first day back, everybody is hanging out when the werecat Toralei Stripe makes an entrance after studying abroad in Scaris, France for a year.

Later, while Clawdeen and Deuce are hanging out, he tells her about how his mother is making him do a traditional year- long gorgon retreat, since Medusa despises Monster High.

Clawdeen wants the post to follow in her mother Selena's footsteps and wants to ensure that witchcraft and half-humans will continue to be allowed at Monster High.

Later, Clawdeen is alone with Frankie and tells her about her stress from Cleo De Nile barraging her with questions on running for prefect, when witches suddenly appear in the room as Draculaura arrives.

Clawdeen and her friends confront Toralei to clarify that Draculaura is innocent, but Bloodgood announces she is putting a school-wide ban on all witchcraft.

Ellis reveals himself as a human to Draculaura and convinces her to go with him to meet his mother Zamara Pure, head of the Salem witch coven, to possibly help end the centuries-old feud between them and vampires.

Zamara arrives to thwart the rescue, but Ellis disillusioned with his mother for manipulating him, helps hold her off so Clawdeen can free Draculaura.

Back at Monster High, the friends celebrate Draculaura's birthday, then they see that Clawdeen has been elected prefect, fully earning Toralei's respect while bonding over shared witch scars.

[9] On March 4, 2023, Miia Harris, Ceci Balagot, Nayah Damasen and Case Walker appeared at the Kids' Choice Awards to promote the film with its sneak peek and teaser.