Tylor Tuskmon, a recent Scare Major graduate from Monsters University, having previously received a letter of acceptance from Waternoose to be a scarer at the factory, is excited to work at the same company as his idol Sulley.

However, Tylor is devastated to learn that the company is no longer in need of scarers, and he is reassigned to work as a mechanic on the Monsters Inc. Facilities Team (MIFT).

In season two, Tylor's position and friendships at Monsters, Incorporated are put at risk when he receives a job offer to work at business rival Fear Co.[8] Other cast members include Bobs Gannaway as Otis, the new Monsters, Incorporated receptionist, and Roto, Duncan's pet,[9] Gabriel Iglesias as Gary Gibbs, Mike Wazowski's arch-nemesis who appears in "The Big Wazowskis" and "Bad Hair Day",[11] and Dee Bradley Baker as Winchester: the non-verbal member of the Monsters, Incorporated Facilities Team, nicknamed "Banana Bread".

Additional monster voices include Carlos Alazraqui, Ferrell Barron, Hiromi Dames, Michaela Dietz, and Dave Wittenberg.

Meanwhile, Mike has been working long hours as both a jokester and a comedy teacher, and the energy crisis begins affecting Monsters, Incorporated.

While celebrating Tylor's first successful repair job, the members of MIFT learn Winchester's actual name (having previously nicknamed him "Banana Bread" as he always brought that for lunch and never spoke) when he resigns to be a jokester after impressing Ms. Flint.

Seeing another opportunity to get rid of him, Duncan tricks Tylor into misleading MIFT into thinking the match has been canceled in exchange for a more skilled team.

MIFT reluctantly agrees to cover up the incident, but things get tense when an inspector from the Monstropolis Energy Regulatory Commission arrives and discovers the truth.

When Mike hears of the situation, he decides to improve company morale by making several outlandish and expensive upgrades to the facility, starting with a brand new vending machine for MIFT.

Tylor gets a chance to become an official jokester when Mike summons his comedy class to the Laugh Floor to help generate power during a heatwave.

After convincing him to go back through the door, Val informs Tylor that Adorable was banished after he discovered a letter from Waternoose regarding Randall's plans for his scream extractor.

Tylor gives up his chance to be a jokester so that he can bring Adorable back to Monstropolis, where Mike and Sulley formally un-banish him and make him the official Monsters, Inc. snow cone vendor.

The other MIFT members are celebrating the anniversary of former employee David who was sucked into a shredder shaft and killed, aside from a lock of hair that they keep in a jar to honor him.

During The Walt Disney Company's earnings call in November 2017, CEO Bob Iger announced that a new series set in the universe of Monsters, Inc., was in development for their planned streaming service Disney+.

He was asked to work on the series after development began, due to his experience on both TV animation and films, having directed the spin-off of Pixar's Cars franchise; Planes: Fire & Rescue.

[26] Anderson joined the series eight months before Disney Television Animation was temporarily closed due to the COVID-19 pandemic, after being approached personally by Gannaway; he ultimately did not direct any of the episodes.

[29] The second season was officially announced at Annecy International Animation Film Festival 2022, with Kevin Deters and Stevie Wermers (the Prep & Landing shorts, Olaf's Frozen Adventure) replacing Gannaway and Anderson as showrunner and supervising director, respectively.

[1] According to Anderson, Pixar assisted the producers on the series by providing notes during its writing and early storyboarding process in order to "keep [them] on track as far as the legacy of the project".

[9] The series also features a new character named Roze, who is Roz's twin sister, as the producers felt that, due to the latter being revealed as the head of the "Child Detection Agency" at the end of the first film, "she wouldn't be back outside the laugh floor".

[9] Gannaway also said he wanted the series to have "the sort of feel of a Pixar story" by making the audience care about Tylor and his personal journey.

[9] In order to get a sense of what it was like working in a factory, the production team visited two power plants and interviewed the workers about their day.

Stevie Wermers-Skelton wanted Monsters, Inc. to represent the "utilitarian blue-collar" type workplace that preaches togetherness while Fear Co. is "basically Google" in that beyond its shiny facade, it has brutal inner workings.

[33] In April 2019, John Goodman and Billy Crystal were confirmed to be returning as both Sullivan and Wazowski for the series alongside John Ratzenberger, Jennifer Tilly, and Bob Peterson, with the new cast including Ben Feldman, Kelly Marie Tran, Henry Winkler, Lucas Neff, Alanna Ubach, Stephen Stanton and Aisha Tyler.

In an interview with The New York Times, it was confirmed that Boo, the human child that Sulley and Mike befriended in the original film, would not be making an appearance.

[7][54] Whip Media, which tracks viewership data for over 1 million daily users worldwide of its TV Time app, calculated that Monsters at Work was the 3rd most-anticipated new streaming television series of July 2021.

[56] Whip Media later reported that Monsters at Work was the top-rising show based on the highest week-over-week growth in episodes watched for the week ended on July 11, 2021.

The website's critics consensus reads, "If Monsters at Work doesn't quite capture the magic of the original film, it's charming and silly enough to entertain fans of all ages.

"[64] Ben Travers of Indiewire gave the show a 'B−' score and stated, "If you love original movies and were expecting a third, Monsters at Work might be a bit disappointing.

"[65] Richard Roeper of Chicago Sun-Times gave the show 3 out of 4 and stated, "Monsters at Work isn't on the same level as the two feature films, but it's miles ahead of the likes of The Return of Jafar or Kronk's New Groove.

"[67] Chris Vognar of San Francisco Chronicle rated the show 2 out of 4 and wrote, "This is a solid effort, even if it doesn't quite shimmer like your top-of-the-line Pixar favorites.