Montesquieu (French pronunciation: [mɔ̃tɛskjø]; Languedocien: Senta Tecla de Montesquiu) is a commune in the Tarn-et-Garonne department in the Occitanie region in southern France.

On the commune's northern border, the Barguelonnette flows into the Barguelonne, which forms all of the commune's northern and northwestern borders.

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