The highway heads east through a junction with Interstate 270 (I-270) before the main course continues as Josiah Henson Memorial Parkway in North Bethesda.

Josiah Henson Memorial Parkway continues through a junction with MD 355, east of which the highway becomes Randolph Road.

The highway continues from US 29 as Cherry Hill Road through an intersection with MD 212 in Calverton before reaching its eastern end at US 1 in College Park.

[1] Montrose Road runs 2.4 miles (3.9 km) from Potomac to Josiah Henson Memorial Parkway in North Bethesda.

[2] Montrose Road continues east from there, but is bypassed by Josiah Henson Memorial Parkway, which has a length of 1.3 miles (2.1 km) to its eastern end beyond MD 355.

Josiah Henson Memorial Parkway continues east with four lanes, crossing over Old Farm Creek.

Josiah Henson Memorial Parkway passes under MD 355 before intersecting ramps to and from northbound MD 355 adjacent to the Montrose Schoolhouse, which is accessed from the adjacent shopping center via Chapman Avenue at the eastern end of Josiah Henson Memorial Parkway.

[3] Montrose Road is state-maintained and designated MD 927A for its easternmost 0.29 miles (0.47 km) from Hoya Street to Chapman Avenue.

Randolph Road intersects Parklawn Drive before passing through a dense suburban residential area.

The highway continues east through a densely populated suburban area, passing by Wheaton High School and through Denley Park before meeting MD 97 (Georgia Avenue) in Glenmont.

The highway passes along the eastern edge of the White Oak Food and Drug Administration campus, then enters Prince George's County shortly before reaching an intersection with MD 212 (Powder Mill Road).

[10] After a large gap from west of Rock Creek to Glenmont, the highway resumed along the present course of Randolph Road except for a deviation at Northwest Branch.

[18] By 1956, Randolph Road was built between Rockville and Glenmont except for a gap between Connecticut Avenue and Bushey Drive to the west halfway to MD 586.

[22] MD 183 was expanded to a divided highway and Randolph Road was placed on its present course at Northwest Branch in 1976.

[26][27] MDSHA plans to construction an urban diamond interchange at the intersection of Randolph Road and MD 97.

Four lanes of Randolph Road will pass under MD 97 while flanking two-lane roadways intersect the state highway and several streets on either side of the interchange.

[28] Montrose Road was straightened out at Cabin John Creek when its bridge across the new Washington National Pike (now I-270) was built in 1956.

[32] Between 1988 and 1991, in conjunction with the expansion of I-270 to 12 lanes, the junction was reconstructed as a full cloverleaf interchange plus ramps with Tower Oaks Boulevard.

[35] The first phase of the creation of Josiah Henson Memorial Parkway included the reconstruction of Montrose Road from Tower Oaks Boulevard to west of Old Farm Creek and construction of Josiah Henson Memorial Parkway from the creek area to the MD 355 interchange.

[37][38] For the next phase of the project, MDSHA will construct Josiah Henson Memorial Parkway's bridge across the railroad and a single-point urban interchange at Parklawn Drive north of Randolph Road.