[5] It is located in the northern part of the country in the Nile Delta, to the south of Gharbia Governorate and to the north of Cairo.

The governorate of Monufia is known for being the birthplace of four Egyptian presidents: Mohammad Anwar el-Sadat, Hosni Mubarak, Adly Mansour, and Abdel Fatah al-Sisi.

The main cities of the governorate are Quesna, Tala, Bagour, Menouf, Ashmoun and Sers El Lyan.

[8] According to the Egyptian Governing Authority for Investment and Free Zones (GAFI), in affiliation with the Ministry of Investment (MOI), the following industrial zones are located in this governorate:[9] In 1826, Mohammed Ali transferred the capital of Monufia from Menouf to Shibin El Kom as the latter fell exactly in the center of the governorate.

In the final round of the 2012 Egyptian presidential election, Monufia had the highest voter turnout rate of all governorates (61.5%) as well as the most overwhelming support for candidate Ahmed Shafik (71.5%).

In 1981, the Basic Village Service Program (BVS), under the auspices of USAID, had several water, road, and other projects, going on in several markazes in the Monufia Governorate.