The Moonee Ponds Junction includes the Clocktower Centre, formerly used as the Essendon Town Hall and council chambers.

Queen's Park was the site of where Burke and Wills camped in 1860 on their expedition from Melbourne to the Gulf of Carpentaria.

Essendon Royals Soccer Club is located in Moonee Ponds and plays in the Victorian State League.

[4] Moonee Ponds station is located at the western end of Puckle Street, on the Craigieburn railway line.

- (20 Robinson Street) Moonee Ponds Junction is the centre of the suburb, with buses, trams and trains all converging in the area.

Moonee Ponds is the location of the office and private home of politician and former Australian Opposition Leader Bill Shorten.

An incomplete list of its other residents includes: The fictitious character of Dame Edna Everage also claimed to be from Moonee Ponds.