Moose River is a town in Somerset County, Maine, United States.

Samuel Holden who in 1820 opened an inn as a stop for cattle drivers en route from Boston to Quebec.

The racial makeup of the town was 96.8% White, 1.4% Native American, 0.5% Asian, and 1.4% from two or more races.

The racial makeup of the town was 96.35% White, 0.46% African American, and 3.20% from two or more races.

23.5% of all households were made up of individuals, and 6.2% had someone living alone who was 65 years of age or older.

About 7.1% of families and 7.3% of the population were below the poverty line, including none of those under the age of eighteen and 27.6% of those 65 or over.