Mopsuestia (Ancient Greek: Μοψουεστία and Μόψου ἑστία, romanized: Mopsou(h)estia and Μόψου Mopsou and Μόψου πόλις and Μόψος; Byzantine Greek: Mamista, Manistra, Mampsista; Arabic: al-Maṣṣīṣah; Armenian: Msis, Mises, Mam(u)estia; modern Yakapınar) is an ancient city in Cilicia Campestris on the Pyramus River (now the Ceyhan River) located approximately 20 km (12 mi) east of ancient Antiochia in Cilicia (present-day Adana, southern Turkey).

[9] Christianity seems to have been introduced very early into Mopsuestia, and during the 3rd century, there is mention of a bishop, Theodorus, the adversary of Paul of Samosata.

Other famous residents of the early Christian period in the city's history include Saint Auxentius (d. 360), and Theodore, bishop from 392–428, the teacher of Nestorius.

In 684 the Emperor Constantine IV recaptured Misis from its small Arab garrison and it remained an imperial possession until 703 (Theophanes, "Chronogr.

In the early 1090s, Turkish forces overran the town, but were expelled in 1097 by Crusader troops under Tancred who took possession of the city and its strategic port, which were annexed to the Principality of Antioch.

Finally, in 1151–1152 the Armenian Baron T'oros II captured the city and defeated the Greek counterattack led by Andronikos I Komnenos.

The Venetians and Genoese were licensed by the Armenians to maintain warehouses near the harbor to store goods brought from India.