The Renfe railway line between Tarragona and Saragossa runs along the left bank of the river, with a station at Móra la Nova opposite the urban centre of Móra d'Ebre.

The most ancient settlements in the area date to 4th millennium BC, to the Neolithic culture of the ditch sepulchres [Wikidata].

The area was reconquered from the Moors in 1153, by count Ramon Berenguer IV of Barcelona.

The baronial castle of Móra d'Ebre is located on a hill overlooking the river and the town.

It is now in a state of semi-ruin, for it was used as a fortress during the Spanish Civil War and was heavily shelled and bombed.