Built in 1872 to serve the Portland and Ogdensburg Railway, the depot was known as the most important train station for the Vermont lumber industry, for its decorative architectural ornament, and for housing the headquarters of the St. Johnsbury and Lamoille County Railroad from 1959 to the early 1970s.

[3] In the beginning of the 19th century, several small towns in Vermont's Green Mountains, including Morristown, began supplying lumber from their forests.

The Central Vermont Railroad was established in 1849 to transport this supply from the mountains to Burlington (the state's commercial center and a port on Lake Champlain).

[4] Although the Portland and Ogdensburg's system was reorganized in 1880, by 1884 the station was popular enough to warrant a 24-by-55-foot (7.3 by 16.8 m) extension in the form of the Depot Restaurant.

[2] The original Portland and Ogdensburg line (now called the St. Johnsbury-Lake Champlain Railroad Company) retook freight operations on the rails.

[8] Although the Morrisville Depot's blueprint was originally a simple rectangle, its ornate decorations made it a striking sight.

The building's original low gable roof projects raking eaves held by trussed chamfered brackets.

Notably missing from the current exterior are the original decorative bargeboards, finials, half-timbered window surrounds, and a wide frieze of patterned woodwork.

The turn of the century poolroom addition was previously a separate specialty grocery store and growler fill shop but has been reconnected to the main depot building.