Moses Leaving for Egypt is a fresco by the Italian Renaissance painter Pietro Perugino and his workshop, executed around 1482 and located in the Sistine Chapel, Rome.

Pope Sixtus IV was pleased by his work, and decided to commission him also the decoration of the new Chapel he had built in the Vatican Palace.

[1] They were painted by Andrea d'Assisi, Rocco Zoppo or, less likely, Lo Spagna or Bartolomeo della Gatta, other Perugino's collaborators of the time.

The painting shows Moses (dressing in yellow and green as in the other frescoes of the cycle) leaving for Egypt, after he had been exiled from Midian, with Zipporah to his right.

The baptism, depicted on the opposite fresco, was in fact considered by several early Christian writers, including Augustine, as a kind of "spiritual circumcision".